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Cell Biol Chapter 11 outline

Ribosomes, Translation, Protein targeting

I. Ribosomes

A. features

1. prokaryote vs. eukaryote

2. 3D model of E. coli ribosome

3. rRNA shapes

4. signature sequences

B. Ribosome biogenesis

1. nucleolus

2. pre-rRNA processing

C. Protein synthesis

1. cell-free systems (in vitro translation)

D. Protein targeting

1. signal sequences for lysosomes, membranes, secretion

2. nuclear localization sequence

3. mitochondria

a) matrix targeting signal

b) inner membrane

c) intermembrane space

d) outer membrane

4. chloroplast

5. peroxisomes

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