Immunology - Tumors (Ch 22)
Tumor Immunology
A. Tumor antigens (tumor associated antigens,
tumor specific antigens)
1. fetal antigens
a. carcinoembryonic Ag (CEA)
b. alpha-fetoprotein
B. Types of cancer
1. carcinomas
2. sarcomas
3. leukemias
4. melanomas
5. benign vs. malignant
C. Causes of cancer
1. chemicals (carcinogens)
2. physical agents (radiation)
3. viruses (oncogenic viruses)
4. genetics
5. oncogenes
D. Host defenses
1. NK cells (and LAK cells - LAK therapy)
2. Macrophages
3. Tc
4. ADCC
E. Therapy
1. conventional = surgery, chemotherapy, radiation
2. stimulate immune system
3. tumor specific immunotoxins
4. photodynamic therapy